Novel Nanocomposite Hydrogels Based on Crosslinked Microbial Polysaccharide as Potential Bioactive Wound Dressings
Maria Minodora Marin,
Madalina Albu Kaya,
Durmus Alpaslan Kaya,
Roxana Constantinescu,
Bogdan Trica,
Ioana Catalina Gifu,
Elvira Alexandrescu,
Cristina Lavinia Nistor,
Rebeca Leu Alexa,
Raluca Ianchis
Affiliations
Maria Minodora Marin
National Research and Development Institute for Textile and Leather, Division Leather and Footwear Research Institute, Department of Collagen, 93 Ion Minulescu Str., 031215 Bucharest, Romania
Madalina Albu Kaya
National Research and Development Institute for Textile and Leather, Division Leather and Footwear Research Institute, Department of Collagen, 93 Ion Minulescu Str., 031215 Bucharest, Romania
Durmus Alpaslan Kaya
National Research and Development Institute for Textile and Leather, Division Leather and Footwear Research Institute, Department of Collagen, 93 Ion Minulescu Str., 031215 Bucharest, Romania
Roxana Constantinescu
National Research and Development Institute for Textile and Leather, Division Leather and Footwear Research Institute, Department of Collagen, 93 Ion Minulescu Str., 031215 Bucharest, Romania
Bogdan Trica
National Research and Development Institute for Chemistry and Petrochemistry ICECHIM, Spl. Independentei 202, 6th District, 0600021 Bucharest, Romania
Ioana Catalina Gifu
National Research and Development Institute for Chemistry and Petrochemistry ICECHIM, Spl. Independentei 202, 6th District, 0600021 Bucharest, Romania
Elvira Alexandrescu
National Research and Development Institute for Chemistry and Petrochemistry ICECHIM, Spl. Independentei 202, 6th District, 0600021 Bucharest, Romania
Cristina Lavinia Nistor
National Research and Development Institute for Chemistry and Petrochemistry ICECHIM, Spl. Independentei 202, 6th District, 0600021 Bucharest, Romania
Rebeca Leu Alexa
Advanced Polymer Materials Group, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 1–7 Polizu Street, 01106 Bucharest, Romania
Raluca Ianchis
National Research and Development Institute for Chemistry and Petrochemistry ICECHIM, Spl. Independentei 202, 6th District, 0600021 Bucharest, Romania
A multitude of dressings have been developed to promote wound repair, such as membranes, foams, hydrocolloids and hydrogels. In this study, a crosslinked polysaccharide hydrogel was mixed with a bioactive ingredient to synthesize a novel nanocomposite material to be used in wound healing. Variation of the ratio between hydrogel components was followed and its effect was analyzed in regard to swelling, degradation rate and thermo-mechanical behavior. The resulting crosslinked structures were characterized by FTIR and microscopy analyses. The antimicrobial activity of the crosslinked hydrogels loaded with bioactive agent was evaluated using two bacterial strains (Gram-positive Staphylococcus aureus and Gram-negative bacteria Escherichia Coli). All the results showed that the new synthesized biopolymer nanocomposites have adequate properties to be used as antibacterial wound dressings.
