Nature Communications (Nov 2019)

Non-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasion

  • Arnab Pradhan,
  • Gabriela M. Avelar,
  • Judith M. Bain,
  • Delma Childers,
  • Chloe Pelletier,
  • Daniel E. Larcombe,
  • Elena Shekhova,
  • Mihai G. Netea,
  • Gordon D. Brown,
  • Lars Erwig,
  • Neil A. R. Gow,
  • Alistair J. P. Brown

DOI
https://doi.org/10.1038/s41467-019-13298-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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The authors show that the fungal pathogen Candida albicans exploits diverse host-associated signals, including specific nutrients and stresses, to promote immune evasion by masking cell wall β-glucan, a major pathogen-associated molecular pattern.