Nature Communications (Jan 2020)
Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection
- Kerri G. Lal,
- Dohoon Kim,
- Margaret C. Costanzo,
- Matthew Creegan,
- Edwin Leeansyah,
- Joana Dias,
- Dominic Paquin-Proulx,
- Leigh Anne Eller,
- Alexandra Schuetz,
- Yuwadee Phuang-ngern,
- Shelly J. Krebs,
- Bonnie M. Slike,
- Hannah Kibuuka,
- Lucas Maganga,
- Sorachai Nitayaphan,
- Josphat Kosgei,
- Carlo Sacdalan,
- Jintanat Ananworanich,
- Diane L. Bolton,
- Nelson L. Michael,
- Barbara L. Shacklett,
- Merlin L. Robb,
- Michael A. Eller,
- Johan K. Sandberg
Affiliations
- Kerri G. Lal
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Dohoon Kim
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Margaret C. Costanzo
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Matthew Creegan
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Edwin Leeansyah
- Center for Infectious Medicine, Department of Medicine, Karolinska Institutet
- Joana Dias
- Center for Infectious Medicine, Department of Medicine, Karolinska Institutet
- Dominic Paquin-Proulx
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Leigh Anne Eller
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Alexandra Schuetz
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Yuwadee Phuang-ngern
- Department of Retrovirology, Armed Forces Research Institute of Medical Sciences
- Shelly J. Krebs
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Bonnie M. Slike
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Hannah Kibuuka
- Makerere University Walter Reed Project
- Lucas Maganga
- National Institute for Medical Research-Mbeya Medical Research Center
- Sorachai Nitayaphan
- Royal Thai Army Component, Armed Forces Research Institute of Medical Sciences
- Josphat Kosgei
- Kenya Medical Research Institute/U.S. Army Medical Research Directorate-Africa/Kenya
- Carlo Sacdalan
- SEARCH, The Thai Red Cross AIDS Research Centre
- Jintanat Ananworanich
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Diane L. Bolton
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Nelson L. Michael
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Barbara L. Shacklett
- Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis
- Merlin L. Robb
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Michael A. Eller
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research
- Johan K. Sandberg
- Center for Infectious Medicine, Department of Medicine, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-019-13975-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Here, using longitudinal pre- and post-infection samples from the RV217 Early Capture HIV Cohort Study, the authors show that mucosa-associated invariant T (MAIT) cells become activated and expand during the early acute phase of HIV infection, with subsequent reprogramming towards innate-like functionality.
