Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex

Jacob Reimer; Matthew J McGinley; Yang Liu; Charles Rodenkirch; Qi Wang; David A McCormick; Andreas S Tolias

doi:10.1038/ncomms13289

Nature Communications (Nov 2016)

Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex

Jacob Reimer,
Matthew J McGinley,
Yang Liu,
Charles Rodenkirch,
Qi Wang,
David A McCormick,
Andreas S Tolias

Affiliations

Jacob Reimer: Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza
Matthew J McGinley: Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza
Yang Liu: Department of Biomedical Engineering, Columbia University
Charles Rodenkirch: Department of Biomedical Engineering, Columbia University
Qi Wang: Department of Biomedical Engineering, Columbia University
David A McCormick: Department of Neuroscience, Yale University
Andreas S Tolias: Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza

DOI: https://doi.org/10.1038/ncomms13289
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 7

Abstract

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In addition to light intensity, changes in pupil diameter are correlated with mental effort, attention and levels of arousal. Reimer et al. report that across behavioural states, fluctuations in pupil diameter are highly correlated with activity of noradrenergic and cholinergic projection neurons.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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