Frontiers in Oncology (Dec 2020)
Consolidation Immunotherapy After Platinum-Based Chemoradiotherapy in Patients With Unresectable Stage III Non-Small Cell Lung Cancer—Cross-Sectional Study of Eligibility and Administration Rates
- Tanja Eichkorn,
- Tanja Eichkorn,
- Farastuk Bozorgmehr,
- Farastuk Bozorgmehr,
- Sebastian Regnery,
- Sebastian Regnery,
- Lisa A. Dinges,
- Lisa A. Dinges,
- Andreas Kudak,
- Andreas Kudak,
- Andreas Kudak,
- Nina Bougatf,
- Nina Bougatf,
- Nina Bougatf,
- Nina Bougatf,
- Dorothea Weber,
- Petros Christopoulos,
- Petros Christopoulos,
- Petros Christopoulos,
- Thomas Muley,
- Thomas Muley,
- Thomas Muley,
- Sonja Kobinger,
- Sonja Kobinger,
- Sonja Kobinger,
- Laila König,
- Laila König,
- Juliane Hörner-Rieber,
- Juliane Hörner-Rieber,
- Juliane Hörner-Rieber,
- Sebastian Adeberg,
- Sebastian Adeberg,
- Claus Peter Heussel,
- Claus Peter Heussel,
- Claus Peter Heussel,
- Claus Peter Heussel,
- Michael Thomas,
- Michael Thomas,
- Michael Thomas,
- Jürgen Debus,
- Jürgen Debus,
- Jürgen Debus,
- Jürgen Debus,
- Jürgen Debus,
- Rami A. El Shafie,
- Rami A. El Shafie
Affiliations
- Tanja Eichkorn
- Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany
- Tanja Eichkorn
- National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany
- Farastuk Bozorgmehr
- National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany
- Farastuk Bozorgmehr
- Thoracic Clinic, Heidelberg University, Heidelberg, Germany
- Sebastian Regnery
- Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany
- Sebastian Regnery
- National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany
- Lisa A. Dinges
- Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany
- Lisa A. Dinges
- National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany
- Andreas Kudak
- Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany
- Andreas Kudak
- National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany
- Andreas Kudak
- Clinical Cooperation Unit Radiation Oncology (E050), German Cancer Research Center (DKFZ), Heidelberg, Germany
- Nina Bougatf
- Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany
- Nina Bougatf
- National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany
- Nina Bougatf
- National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany
- Nina Bougatf
- Clinical Cooperation Unit Radiation Oncology (E050), German Cancer Research Center (DKFZ), Heidelberg, Germany
- Dorothea Weber
- Institute for Medical Biometrics and Informatics, Heidelberg University, Heidelberg, Germany
- Petros Christopoulos
- National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany
- Petros Christopoulos
- Thoracic Clinic, Heidelberg University, Heidelberg, Germany
- Petros Christopoulos
- Translational Lung Research Center Heidelberg (TLRC-H, German Center for Lung Research (DZL), Heidelberg, Germany
- Thomas Muley
- National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany
- Thomas Muley
- Thoracic Clinic, Heidelberg University, Heidelberg, Germany
- Thomas Muley
- Translational Lung Research Center Heidelberg (TLRC-H, German Center for Lung Research (DZL), Heidelberg, Germany
- Sonja Kobinger
- National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany
- Sonja Kobinger
- Thoracic Clinic, Heidelberg University, Heidelberg, Germany
- Sonja Kobinger
- Translational Lung Research Center Heidelberg (TLRC-H, German Center for Lung Research (DZL), Heidelberg, Germany
- Laila König
- Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany
- Laila König
- National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany
- Juliane Hörner-Rieber
- Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany
- Juliane Hörner-Rieber
- National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany
- Juliane Hörner-Rieber
- Clinical Cooperation Unit Radiation Oncology (E050), German Cancer Research Center (DKFZ), Heidelberg, Germany
- Sebastian Adeberg
- Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany
- Sebastian Adeberg
- National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany
- Claus Peter Heussel
- National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany
- Claus Peter Heussel
- Translational Lung Research Center Heidelberg (TLRC-H, German Center for Lung Research (DZL), Heidelberg, Germany
- Claus Peter Heussel
- Department of Diagnostic and Interventional Radiology, Thoracic Clinic, Heidelberg University, Heidelberg, Germany
- Claus Peter Heussel
- Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoracic Clinic, Heidelberg University, Heidelberg, Germany
- Michael Thomas
- National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany
- Michael Thomas
- Thoracic Clinic, Heidelberg University, Heidelberg, Germany
- Michael Thomas
- Translational Lung Research Center Heidelberg (TLRC-H, German Center for Lung Research (DZL), Heidelberg, Germany
- Jürgen Debus
- Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany
- Jürgen Debus
- National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany
- Jürgen Debus
- National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany
- Jürgen Debus
- Clinical Cooperation Unit Radiation Oncology (E050), German Cancer Research Center (DKFZ), Heidelberg, Germany
- Jürgen Debus
- 0German Cancer Consortium (DKTK), Partner Site Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany
- Rami A. El Shafie
- Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany
- Rami A. El Shafie
- National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany
- DOI
- https://doi.org/10.3389/fonc.2020.586449
- Journal volume & issue
-
Vol. 10
Abstract
IntroductionThe PACIFC trial demonstrated a significant benefit of durvalumab consolidation immunotherapy (CIT) after definitive platinum-based chemoradiotherapy (P-CRT) for survival in stage III non-small cell lung cancer (NSCLC). It is unknown how many patients are eligible in clinical practice to receive CIT according to PACIFIC criteria compared to real administration rates and what influencing factors are.Patients and MethodsWe analyzed 442 patients with unresectable stage III NSCLC who received P-CRT between 2009 and 2019 regarding CIT eligibility rates according to PACIFIC criteria and administration rates since drug approval.ResultsSixty-four percent of 437 patients were male, median age was 63 years [interquartile range (IQR): 57–69]. The most common histologic subtypes were adenocarcinoma (42.8%) and squamous cell carcinoma (41.1%), most tumors were in stage IIIB (56.8%). Mean PD-L1 tumor proportion score (TPS) was 29.8% (IQR: 1–60). The median total RT dose was 60 Gy (IQR: 60–66). Platinum component of P-CRT was evenly distributed between cisplatin (51.4%) and carboplatin (48.6%). 50.3% of patients were eligible for CIT according to PACIFIC criteria. Observed contraindications were progressive disease according to RECIST (32.4%), followed by a PD-L1 TPS < 1% (22.3%), pneumonitis CTCAE ≥ 2 (12.6%) and others (4.9%). One year after drug approval, 85.6% of patients who were eligible according to PACIFIC criteria actually received CIT. Time interval between chemotherapy start and radiation therapy start (OR 0.9, 95% CI: [0.9; 1.0] p = 0.009) and probably cisplatin as platinum-component of P-CRT (OR 1.5, 95% CI: [1.0; 2.4] p < 0.061) influence CIT eligibility. Highly positive PD-L1 TPS (≥50%; (OR 2.4, 95% CI: [1.3; 4.5] p = 0.004) was associated to a better chance for CIT eligibility.ConclusionEighty-five percent of potentially eligible patients received CIT one year after drug approval. Fifty percent of patients did not meet PACIFIC criteria for durvalumab eligibility, this was mainly caused by disease progression during platinum-based CRT, followed by therapy-related pneumonitis and PD-L1 TPS < 1% (in view of the EMA drug approval).
Keywords
- durvalumab eligibility rate
- durvalumab admission rate
- PACIFIC criteria
- non-small cell lung cancer stage III
- definitive platinum-based chemoradiotherapy