Peripheral T-Cell Lymphomas of the T Follicular Helper Type: Clinical, Pathological, and Genetic Attributes

Karthik A. Ganapathi; Kristin H. Karner; Madhu P. Menon

doi:10.3390/hemato3010020

Hemato (Mar 2022)

Peripheral T-Cell Lymphomas of the T Follicular Helper Type: Clinical, Pathological, and Genetic Attributes

Karthik A. Ganapathi,
Kristin H. Karner,
Madhu P. Menon

Affiliations

Karthik A. Ganapathi: Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
Kristin H. Karner: ARUP Laboratories and Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
Madhu P. Menon: ARUP Laboratories and Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA

DOI: https://doi.org/10.3390/hemato3010020
Journal volume & issue: Vol. 3, no. 1
pp. 268 – 286

Abstract

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Follicular helper T-cell (TFH) lymphomas comprise a unique group of T-cell lymphomas that represent neoplastic proliferations of follicular helper T-cells and share genetic, immunophenotypic, morphologic, and clinical features. Angioimmunoblastic T-cell lymphoma (AITL) is the prototypical TFH lymphoma; in addition, the 2017 revised World Health Organization (WHO) 4th edition recognizes two other unique subtypes: follicular T-cell lymphoma (FTCL) and nodal peripheral T-cell lymphoma with the T follicular helper phenotype (PTCL-TFH). This review discusses the morphologic spectrum, immunophenotype, diagnostic mimics/pitfalls, and unique genetic attributes of this category of T-cell lymphomas.

Published in Hemato

ISSN: 2673-6357 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: https://www.mdpi.com/journal/hemato

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Abstract

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