The Essential Oil of Artemisia argyi H.Lév. and Vaniot Attenuates NLRP3 Inflammasome Activation in THP-1 Cells

Pengxiao Chen; Pengxiao Chen; Pengxiao Chen; Qi Bai; Qi Bai; Yanting Wu; Yanting Wu; Qiongzhen Zeng; Qiongzhen Zeng; Xiaowei Song; Xiaowei Song; Yuying Guo; Pengjun Zhou; Yao Wang; Xiaofeng Liao; Qiaoli Wang; Zhe Ren; Zhe Ren; Yifei Wang; Yifei Wang

doi:10.3389/fphar.2021.712907

Frontiers in Pharmacology (Sep 2021)

The Essential Oil of Artemisia argyi H.Lév. and Vaniot Attenuates NLRP3 Inflammasome Activation in THP-1 Cells

Pengxiao Chen,
Pengxiao Chen,
Pengxiao Chen,
Qi Bai,
Qi Bai,
Yanting Wu,
Yanting Wu,
Qiongzhen Zeng,
Qiongzhen Zeng,
Xiaowei Song,
Xiaowei Song,
Yuying Guo,
Pengjun Zhou,
Yao Wang,
Xiaofeng Liao,
Qiaoli Wang,
Zhe Ren,
Zhe Ren,
Yifei Wang,
Yifei Wang

Affiliations

Pengxiao Chen: Guangzhou Jinan Biomedicine Research and Development Center, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Pengxiao Chen: Key Laboratory of Bioengineering Medicine of Guangdong Province, Guangzhou, China
Pengxiao Chen: Biology Postdoctoral Research Station, Jinan University, Guangzhou, China
Qi Bai: Guangzhou Jinan Biomedicine Research and Development Center, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Qi Bai: Key Laboratory of Bioengineering Medicine of Guangdong Province, Guangzhou, China
Yanting Wu: Guangzhou Jinan Biomedicine Research and Development Center, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Yanting Wu: Key Laboratory of Bioengineering Medicine of Guangdong Province, Guangzhou, China
Qiongzhen Zeng: Guangzhou Jinan Biomedicine Research and Development Center, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Qiongzhen Zeng: Key Laboratory of Bioengineering Medicine of Guangdong Province, Guangzhou, China
Xiaowei Song: Guangzhou Jinan Biomedicine Research and Development Center, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Xiaowei Song: Key Laboratory of Bioengineering Medicine of Guangdong Province, Guangzhou, China
Yuying Guo: Guangzhou Jinan Biomedicine Research and Development Center, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Pengjun Zhou: The First Affiliated Hospital of Jinan University, Guangzhou Overseas Chinese Hospital, Guangzhou, China
Yao Wang: Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China
Xiaofeng Liao: Guangzhou Jinan Biomedicine Research and Development Center, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Qiaoli Wang: Guangzhou Jinan Biomedicine Research and Development Center, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Zhe Ren: Guangzhou Jinan Biomedicine Research and Development Center, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Zhe Ren: Key Laboratory of Bioengineering Medicine of Guangdong Province, Guangzhou, China
Yifei Wang: Guangzhou Jinan Biomedicine Research and Development Center, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Yifei Wang: Key Laboratory of Bioengineering Medicine of Guangdong Province, Guangzhou, China

DOI: https://doi.org/10.3389/fphar.2021.712907
Journal volume & issue: Vol. 12

Abstract

Read online

Artemisia argyi H. Lév. and Vaniot is a traditional medical herb that has been used for a long time in China and other Asian counties. Essential oil is the main active fraction of Artemisia argyi H. Lév. and Vaniot, and its anti-inflammatory potential has been observed in vitro and in vivo. Here, we found that the essential oil of Artemisia argyi H. Lév. and Vaniot (EOAA) inhibited monosodium urate (MSU)- and nigericin-induced NLRP3 inflammasome activation. EOAA suppressed caspase-1 and IL-1β processing and pyroptosis. NF-κB p65 phosphorylation and translocation were also inhibited. In addition, EOAA suppressed nigericin-induced NLRP3 inflammasome activation without blocking ASC oligomerization, suggesting that it may inhibit NLRP3 inflammasome activation by preventing caspase-1 processing. Our study thus indicates that EOAA inhibits NLRP3 inflammasome activation and has therapeutic potential against NLRP3-driven diseases.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

About the journal

Abstract

Keywords