Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells
Changjun Chen,
Songgang Wang,
Jiying Chen,
Xiaolin Liu,
Mengchen Zhang,
Xi Wang,
Weihua Xu,
Yayun Zhang,
Hao Li,
Xin Pan,
Meng Si
Affiliations
Changjun Chen
Department of Orthopedics Qilu Hospital of Shandong University Jinan China
Songgang Wang
Department of Orthopedics Qilu Hospital of Shandong University Jinan China
Jiying Chen
The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education Chinese Ministry of Health the State Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine Qilu Hospital of Shandong University Jinan Shandong China
Xiaolin Liu
The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education Chinese Ministry of Health the State Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine Qilu Hospital of Shandong University Jinan Shandong China
Mengchen Zhang
Department of Orthopedics Qilu Hospital of Shandong University Jinan China
Xi Wang
Department of Orthopedics Qilu Hospital of Shandong University Jinan China
Weihua Xu
Department of Orthopedics Qilu Hospital of Shandong University Jinan China
Yayun Zhang
Department of Orthopedics Qilu Hospital of Shandong University Jinan China
Hao Li
Department of Orthopedics Qilu Hospital of Shandong University Jinan China
Xin Pan
Department of Orthopedics Qilu Hospital of Shandong University Jinan China
Meng Si
Department of Orthopedics Qilu Hospital of Shandong University Jinan China
Escin, a natural triterpene saponin mixture obtained from the horse chestnut tree (Aesculus hippocastanum), has been used for the treatment of chronic venous insufficiency (CVI), hemorrhoids, and edema. However, it is unclear how escin protects against endothelial barrier dysfunction induced by pro‐inflammatory high mobility group protein 1 (HMGB1). Here, we report that escin can suppress (a) HMGB1‐induced overexpression of the aquaporin‐1 (AQP1) water channel in endothelial cells and (b) HMGB1‐induced increases in endothelial cell permeability. This is the first report that escin inhibits AQP1 and alleviates barrier dysfunction in HMGB1‐induced inflammatory response.
