Nature Communications (Sep 2021)

Programmable receptors enable bacterial biosensors to detect pathological biomarkers in clinical samples

  • Hung-Ju Chang,
  • Ana Zúñiga,
  • Ismael Conejero,
  • Peter L. Voyvodic,
  • Jerome Gracy,
  • Elena Fajardo-Ruiz,
  • Martin Cohen-Gonsaud,
  • Guillaume Cambray,
  • Georges-Philippe Pageaux,
  • Magdalena Meszaros,
  • Lucy Meunier,
  • Jerome Bonnet

DOI
https://doi.org/10.1038/s41467-021-25538-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Bacterial biosensors have promising applications in medical and environmental diagnostics. Here the authors use EMeRALD synthetic receptors to design bile salt sensors for use in liver transplant patient serum.