Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin

Yu Wang; Shanshan Jin; Dan Luo; Danqing He; Chunyan Shi; Lisha Zhu; Bo Guan; Zixin Li; Ting Zhang; Yanheng Zhou; Cun-Yu Wang; Yan Liu

doi:10.1038/s41467-021-21545-1

Nature Communications (Feb 2021)

Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin

Yu Wang,
Shanshan Jin,
Dan Luo,
Danqing He,
Chunyan Shi,
Lisha Zhu,
Bo Guan,
Zixin Li,
Ting Zhang,
Yanheng Zhou,
Cun-Yu Wang,
Yan Liu

Affiliations

Yu Wang: Laboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology
Shanshan Jin: Laboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology
Dan Luo: State Key Laboratory of Heavy Oil Processing, College of New Energy and Materials, Beijing Key Laboratory of Biogas Upgrading Utilization, China University of Petroleum (Beijing)
Danqing He: Laboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology
Chunyan Shi: Department of Radiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung & Vascular Diseases, Capital Medical University
Lisha Zhu: Laboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology
Bo Guan: Beijing National Laboratory for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences
Zixin Li: Laboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology
Ting Zhang: Laboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology
Yanheng Zhou: Laboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology
Cun-Yu Wang: Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry and Jonsson Comprehensive Cancer Center, University of California Los Angeles
Yan Liu: Laboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology

DOI: https://doi.org/10.1038/s41467-021-21545-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

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The regeneration of functional tendons remains a clinical challenge. Here the authors develop a biomimetic scaffold loaded with recombinant periostin and demonstrate its functionality in promoting tendon stem/progenitor cell recruitment and tenogenic differentiation, and tendon regeneration in a rat full-cut Achilles tendon defect model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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