A54T polymorphism in fatty acid binding protein 2 gene is associated in Type 2 Diabetes Mellitus in adult subjects

Abstract

Type 2 Diabetes Mellitus (T2DM) is a chronic, non-communicable and complex, metabolic disease caused by resistance to insulin. The role of FABP2 in T2DM has been confirmed via genomic studies. Genetic studies related to Ala54Thr (A54T) polymorphism in FABP2 in the Pakistani population are lacking. The objective of the present study was to analyze the prevalence of A54T polymorphism among those diagnosed with T2DM in the Pakistani population. Clinical and genotype data were statistically analyzed. Baseline and demographic characteristics of T2DM cases and controls were evaluated. Genotype analysis indicated a significant association between T2DM cases and the Thr genotype, Thr allele, and genetic models (p < 0.05), compared with controls. T2DM was significantly associated with Ala54Thr polymorphism in FABP2 in the Pakistani population. The T2DM risk in the studied population was assessed via genotype analysis and diagnostic criteria. T2DM was significantly associated with Ala54Thr polymorphism in FABP2 in the Pakistani population. Keywords: T2DM, FABP2 gene, Ala54Thr, Fatty-acids