Requirements for diploid allogenic cell lines used for regenerative medicine

Abstract

Cell transplantation becomes a mode of correcting the functional failure of organs and tissues in injury and a number of diseases. The paper considers the issues concerning the biological safety of therapy with differential cells: in vitro cultured fibroblasts. The Russian line M-22 derived from the skin and muscle of diploid human embryonic cells has persisted just for more than 40 years and successfully used to treat patients with severe burns.

Keywords

• stem cell transplantation
• biological safety
• diploid cell line