Frontiers in Medicine (Aug 2025)
Case Report: IVCM of corneal chlorpromazine toxicity drug deposits
- Xianwen Xiao,
- Xianwen Xiao,
- Xianwen Xiao,
- Xianwen Xiao,
- Xianwen Xiao,
- Xianwen Xiao,
- Xie Fang,
- Xie Fang,
- Xie Fang,
- Xie Fang,
- Xie Fang,
- Xie Fang,
- Zhiwen Xie,
- Zhiwen Xie,
- Zhiwen Xie,
- Zhiwen Xie,
- Zhiwen Xie,
- Zhiwen Xie,
- Shunrong Luo,
- Shunrong Luo,
- Shunrong Luo,
- Shunrong Luo,
- Shunrong Luo,
- Shunrong Luo,
- Yuan Lin,
- Yuan Lin,
- Yuan Lin,
- Yuan Lin,
- Yuan Lin,
- Yuan Lin,
- Huping Wu,
- Huping Wu,
- Huping Wu,
- Huping Wu,
- Huping Wu,
- Huping Wu
Affiliations
- Xianwen Xiao
- Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, China
- Xianwen Xiao
- Xiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, China
- Xianwen Xiao
- Xiamen Key Laboratory of Ophthalmology, Xiamen, Fujian, China
- Xianwen Xiao
- Fujian Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China
- Xianwen Xiao
- Xiamen Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China
- Xianwen Xiao
- Translational Medicine Institute of Xiamen Eye Center of Xiamen University, Xiamen, Fujian, China
- Xie Fang
- Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, China
- Xie Fang
- Xiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, China
- Xie Fang
- Xiamen Key Laboratory of Ophthalmology, Xiamen, Fujian, China
- Xie Fang
- Fujian Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China
- Xie Fang
- Xiamen Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China
- Xie Fang
- Translational Medicine Institute of Xiamen Eye Center of Xiamen University, Xiamen, Fujian, China
- Zhiwen Xie
- Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, China
- Zhiwen Xie
- Xiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, China
- Zhiwen Xie
- Xiamen Key Laboratory of Ophthalmology, Xiamen, Fujian, China
- Zhiwen Xie
- Fujian Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China
- Zhiwen Xie
- Xiamen Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China
- Zhiwen Xie
- Translational Medicine Institute of Xiamen Eye Center of Xiamen University, Xiamen, Fujian, China
- Shunrong Luo
- Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, China
- Shunrong Luo
- Xiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, China
- Shunrong Luo
- Xiamen Key Laboratory of Ophthalmology, Xiamen, Fujian, China
- Shunrong Luo
- Fujian Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China
- Shunrong Luo
- Xiamen Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China
- Shunrong Luo
- Translational Medicine Institute of Xiamen Eye Center of Xiamen University, Xiamen, Fujian, China
- Yuan Lin
- Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, China
- Yuan Lin
- Xiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, China
- Yuan Lin
- Xiamen Key Laboratory of Ophthalmology, Xiamen, Fujian, China
- Yuan Lin
- Fujian Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China
- Yuan Lin
- Xiamen Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China
- Yuan Lin
- Translational Medicine Institute of Xiamen Eye Center of Xiamen University, Xiamen, Fujian, China
- Huping Wu
- Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen, China
- Huping Wu
- Xiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, China
- Huping Wu
- Xiamen Key Laboratory of Ophthalmology, Xiamen, Fujian, China
- Huping Wu
- Fujian Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China
- Huping Wu
- Xiamen Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian, China
- Huping Wu
- Translational Medicine Institute of Xiamen Eye Center of Xiamen University, Xiamen, Fujian, China
- DOI
- https://doi.org/10.3389/fmed.2025.1614699
- Journal volume & issue
-
Vol. 12
Abstract
To investigate corneal deposits in a patient undergoing long-term chlorpromazine therapy using in vivo confocal microscopy with the HRT II Rostock Corneal Module. We reported a 45-year-old woman with a 7-year history of chlorpromazine therapy presented with bilateral photophobia and a 4-year history of gradual-onset blurred vision. Slit-lamp examination revealed yellowish deposits in the corneal endothelium and Descemet’s membrane. In vivo confocal microscopy identified irregular hyper-reflective deposits in all corneal layers. The epithelial and superficial stromal deposits had well-defined edges, while the posterior stromal, Descemet’s membrane, and endothelial deposits appeared as hollow granules and streaks. This study is the first to use in vivo confocal microscopy to identify crystalline deposits in the corneal stroma and endothelium caused by high-dose chlorpromazine. These findings offer new insights into drug metabolism on the ocular surface and provide a basis for future research.
Keywords
