Risk of antibiotics associated with Clostridioides difficile infection: Antibiotic stewardship in action

Andrew T. Dysangco; Tamra M. Pierce; Dawn M. Bravata

doi:10.1017/ash.2022.286

Antimicrobial Stewardship & Healthcare Epidemiology (Jan 2022)

Risk of antibiotics associated with Clostridioides difficile infection: Antibiotic stewardship in action

Andrew T. Dysangco,
Tamra M. Pierce,
Dawn M. Bravata

Affiliations

Andrew T. Dysangco: ORCiD; Department of Veterans’ Affairs (VA) Health Services Research and Development (HSR&D) Precision Monitoring to Transform Care (PRISM) Quality Enhancement Research Initiative (QUERI), Indianapolis, Indiana VA HSR&D Center for Health Information and Communication (CHIC), Richard L. Roudebush VA Medical Center, Indianapolis, Indiana Medicine Service, Richard L. Roudebush VA Medical Center, Indianapolis, Indiana Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana
Tamra M. Pierce: Pharmacy Service, Richard L. Roudebush VA Medical Center, Indianapolis, Indiana
Dawn M. Bravata: ORCiD; Department of Veterans’ Affairs (VA) Health Services Research and Development (HSR&D) Precision Monitoring to Transform Care (PRISM) Quality Enhancement Research Initiative (QUERI), Indianapolis, Indiana VA HSR&D Center for Health Information and Communication (CHIC), Richard L. Roudebush VA Medical Center, Indianapolis, Indiana Medicine Service, Richard L. Roudebush VA Medical Center, Indianapolis, Indiana Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana Regenstrief Institute, Indianapolis, Indiana

DOI: https://doi.org/10.1017/ash.2022.286
Journal volume & issue: Vol. 2

Abstract

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We examined risk associated with antibiotics used for Clostridioides difficile infection (CDI) at a single site from 2018 through 2020. Overall, 78 patients had nonrecurrent infections. Among inpatient antibiotics, intravenous meropenem had the highest CDI rate (3.56 per 1,000 days of therapy; n = 2 cases). Among outpatient antibiotics, metronidazole had the highest rate (0.071 per 1,000 pills dispensed; n = 3 cases).

Published in Antimicrobial Stewardship & Healthcare Epidemiology

ISSN: 2732-494X (Online)
Publisher: Cambridge University Press
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.cambridge.org/core/journals/antimicrobial-stewardship-and-healthcare-epidemiology

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