Synthesis and Pharmacological Evaluation of [11C]4-Methoxy‑N‑[2-(thiophen-2-yl)imidazo[1,2‑a]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the δ‑Subunit-Containing γ‑Aminobutyric Acid Type A Receptors

• Elina T. L’Estrade,
• Hanne D. Hansen,
• Christina Falk-Petersen,
• Anne Haugaard,
• Nane Griem-Krey,
• Sascha Jung,
• Hartmut Lüddens,
• Tanja Schirmeister,
• Maria Erlandsson,
• Tomas Ohlsson,
• Gitte M. Knudsen,
• Matthias M. Herth,
• Petrine Wellendorph,
• Bente Frølund

Affiliations

Elina T. L’Estrade

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Hanne D. Hansen

Neurobiology Research Unit and CIMBI, Copenhagen University Hospital, Copenhagen, Denmark

Christina Falk-Petersen

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Anne Haugaard

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Nane Griem-Krey

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Sascha Jung

Institute of Pharmacy & Biochemistry, Johannes Gutenberg University, Mainz, Germany

Hartmut Lüddens

Department of Psychiatry and Psychotherapy, Faculty of Health and Medical Sciences, University of Medical Center, Mainz, Germany

Tanja Schirmeister

Institute of Pharmacy & Biochemistry, Johannes Gutenberg University, Mainz, Germany

Maria Erlandsson

Radiation Physics, Nuclear Medicine Physics Unit, Skånes University Hospital, Lund, Sweden

Tomas Ohlsson

Radiation Physics, Nuclear Medicine Physics Unit, Skånes University Hospital, Lund, Sweden

Gitte M. Knudsen

Neurobiology Research Unit and CIMBI, Copenhagen University Hospital, Copenhagen, Denmark

Matthias M. Herth

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Petrine Wellendorph

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Bente Frølund

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark