Nature Communications (Dec 2022)
Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseases
- A. Schäbitz,
- C. Hillig,
- M. Mubarak,
- M. Jargosch,
- A. Farnoud,
- E. Scala,
- N. Kurzen,
- A. C. Pilz,
- N. Bhalla,
- J. Thomas,
- M. Stahle,
- T. Biedermann,
- C. B. Schmidt-Weber,
- F. Theis,
- N. Garzorz-Stark,
- K. Eyerich,
- M. P. Menden,
- S. Eyerich
Affiliations
- A. Schäbitz
- Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet
- C. Hillig
- Institute of Computational Biology, Helmholtz Zentrum München—German Research Centre for Environmental Health
- M. Mubarak
- Center for Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich
- M. Jargosch
- Center for Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich
- A. Farnoud
- Institute of Computational Biology, Helmholtz Zentrum München—German Research Centre for Environmental Health
- E. Scala
- Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet
- N. Kurzen
- Center for Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich
- A. C. Pilz
- Department of Dermatology and Allergy, Technical University of Munich
- N. Bhalla
- Department of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology
- J. Thomas
- Center for Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich
- M. Stahle
- Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet
- T. Biedermann
- Department of Dermatology and Allergy, Technical University of Munich
- C. B. Schmidt-Weber
- Center for Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich
- F. Theis
- Institute of Computational Biology, Helmholtz Zentrum München—German Research Centre for Environmental Health
- N. Garzorz-Stark
- Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet
- K. Eyerich
- Division of Dermatology and Venereology, Department of Medicine Solna, and Center for Molecular Medicine, Karolinska Institutet
- M. P. Menden
- Institute of Computational Biology, Helmholtz Zentrum München—German Research Centre for Environmental Health
- S. Eyerich
- Center for Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich
- DOI
- https://doi.org/10.1038/s41467-022-35319-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Inflammatory skin diseases involve various different immune cells in a localised area. Here the authors use spatial transcriptomics to show that disease relevant cytokine transcripts are sparsely expressed in lesional skin, yet are associated with local amplification cascades that promote skin inflammation.
