Antarite - synergistic combination of «magaldrat + simethicone» with gastroprotective properties

Abstract

Resume. TThe preparation "Antarite” is a combination of magaldrate (antacid of a new generation) with simethicone (antifoam component to reduce flatulence). The antacid effect of the drug develops quickly (1-2 minutes) and lasts for a long time (up to 3 hours). Magaldrat is antacid of multitarget effect, exhibiting a pronounced cytoprotective effect on the gastric mucosa. When the galdrate is dissolved in the hydrochloric acid of the stomach, the crystal structure of this substance causes the formation of tightly packed aluminum hydroxide particles. These particles envelop the area of ulceration, and the size of these particles (2 microns) is such that it facilitates the migration of epithelial cells and fibroblasts in the process of repair of the stomach wall. Additional curative effects of magaldrate are associated with the gradual secretion of magnesium and aluminum ions (hexa-aluminum), which help to maintain optimal concentrations of these ions. The biological effects of aluminum ions are accomplished by activating G-proteins and inhibiting adenylate cyclases. As a result, the metabolism of prostaglandins is modulated, the levels of the vasodilator of nitric oxide (NO) increase, and antihistamine effects are manifested - important components of the multitarget action of magaldrate.

Keywords

• антациды
• g-белки
• магалдрат
• антарейт
• фармакокинетика
• фармакодинамика
• интеллектуальный анализ данных
• antacids
• g-proteins
• magaldrat
• antarite
• pharmacokinetics
• pharmacodynamics
• data mining