Scientific Reports (Jan 2025)

Red blood cell parameters as biomarkers of retinopathy of prematurity in preterm infants born before 30 weeks of gestation

  • Hajime Maeda,
  • Hayato Go,
  • Hajime Iwasa,
  • Shun Hiruta,
  • Hirotaka Ichikawa,
  • Yukinori Sugano,
  • Kei Ogasawara,
  • Nobuo Momoi,
  • Tetsuju Sekiryu,
  • Mitsuaki Hosoya

DOI
https://doi.org/10.1038/s41598-024-84030-x
Journal volume & issue
Vol. 15, no. 1
pp. 1 – 8

Abstract

Read online

Abstract Retinopathy of prematurity (ROP) is a major cause of preventable blindness in preterm infants. The association between red blood cell (RBC) parameters and the development of ROP remains unclear. The objectives of the present study were to evaluate the association between RBC parameters and ROP treatment. This single-center, retrospective cohort study included preterm infants born at 117.3 fL at birth (adjusted odds ratio [aOR]:2.3; 95% confidence intervals CI 1.0–5.3). Additionally, on DOL 28, hemoglobin (Hb) values 18.5% (aOR:2.6; 95% CI 1.1–6.2) were associated with ROP treatment. In conclusion, our study indicated that infants born at 117.3 fL at birth, along with Hb 18.5% on DOL 28, had an increased risk of requiring ROP, warranting treatment.