Nature Communications (Jul 2019)

Facile access to nitroarenes and nitroheteroarenes using N-nitrosaccharin

  • Roxan Calvo,
  • Kun Zhang,
  • Alessandro Passera,
  • Dmitry Katayev

DOI
https://doi.org/10.1038/s41467-019-11419-y
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 8

Abstract

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Nitro(hetero) arenes are valuable intermediates in organic synthesis, therefore mild and safe methods to nitrate C-H bonds remain desirable. Here, the authors report a bench-stable, inexpensive, easy to synthesize and recyclable nitrating reagent based on saccharin, allowing for nitration of (hetero)arenes with broad scope.