Short term effects of latanoprost on intraocular pressure, central corneal thickness and anterior chamber depth in open angle glaucoma

Abstract

AIM:To investigate the changes in intraocular pressure(IOP), central corneal thickness(CCT)and anterior chamber depth(ACD)in eyes with open angle glaucoma treated with topical latanoprost(0.005%, once a day)for 6mo.METHODS:Thirty seven eyes of 24 newly diagnosed patients with primary open-angle glaucoma(POAG)or pseudoexfoliation glaucoma(PXG)were included. IOP was measured with Goldmann applanation tonometry, CCT was measured with ultrasound pachymeter, while ACD and ACD/axial length(AL)values were obtained by ultrasound biometry. IOP, CCT, ACD and ACD/AL measurements before treatment were compared with the recordings at the 3mo and the 6mo of treatment.RESULTS: Mean IOP values at baseline, and at 3mo and 6mo were, 25.0±4.2, 17.5±2.0 and 16.9±1.7, respectively, showing a significant reduction after treatment. Mean CCT values at baseline, and at 3mo and 6mo were, 546.6±31.5, 541.0±29.4 and 542.2±29.3, respectively, showing a significant reduction after treatment. Mean ACD values at baseline, and at 3mo and 6mo were, 3.00±0.43, 2.95±0.42 and 2.97±0.41, respectively, showing a significant reduction at 3mo, but not at 6mo. ACD/AL changes after treatment were similar to the ACD course. The significant changes in CCT and ACD measurements were found to be related with the POAG eyes, not with the PXG eyes, when evaluated separately.CONCLUSION:Apart from a substantial reduction in IOP, latanoprost induces corneal thinning and ACD reduction at the short term of treatment in eyes with open angle glaucoma.

Keywords

• latanoprost
• open angle glaucoma
• central corneal thickness
• anterior chamber depth
• intraocular pressure