Frugal and Translatable [15O]O2 Production for Human Inhalation with Direct Delivery from the Cyclotron to a Hybrid PET/MR

Jeffrey Corsaut; Elmer Soto; Heather Biernaski; Michael S. Kovacs; Keith St. Lawrence; Justin W. Hicks

doi:10.3390/diagnostics14090902

Diagnostics (Apr 2024)

Frugal and Translatable [15O]O2 Production for Human Inhalation with Direct Delivery from the Cyclotron to a Hybrid PET/MR

Jeffrey Corsaut,
Elmer Soto,
Heather Biernaski,
Michael S. Kovacs,
Keith St. Lawrence,
Justin W. Hicks

Affiliations

Jeffrey Corsaut: Lawson Health Research Institute, London, ON N6A 5W9, Canada
Elmer Soto: Lawson Health Research Institute, London, ON N6A 5W9, Canada
Heather Biernaski: Lawson Health Research Institute, London, ON N6A 5W9, Canada
Michael S. Kovacs: Lawson Health Research Institute, London, ON N6A 5W9, Canada
Keith St. Lawrence: Lawson Health Research Institute, London, ON N6A 5W9, Canada
Justin W. Hicks: Lawson Health Research Institute, London, ON N6A 5W9, Canada

DOI: https://doi.org/10.3390/diagnostics14090902
Journal volume & issue: Vol. 14, no. 9
p. 902

Abstract

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Oxygen-15 (β+, t1/2 = 122 s) radiolabeled diatomic oxygen, in conjunction with positron emission tomography, is the gold standard to quantitatively measure the metabolic rate of oxygen consumption in the living human brain. We present herein a protocol for safe and effective delivery of [15O]O2 over 200 m to a human subject for inhalation. A frugal quality control testing procedure was devised and validated. This protocol can act as a blueprint for other sites seeking to implement similar imaging programs.

Published in Diagnostics

ISSN: 2075-4418 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.mdpi.com/journal/diagnostics

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