Cancer Management and Research (Apr 2021)
Clinical Value of Detecting Tumor Endothelial Marker 8 (ANTXR1) as a Biomarker in the Diagnosis and Prognosis of Colorectal Cancer
Abstract
Łukasz Pietrzyk,1,2 Agnieszka Korolczuk,3 Małgorzata Matysek,4 Marcin B Arciszewski,4 Kamil Torres1 1Department of Didactics and Medical Simulation, Faculty of Medicine, Medical University of Lublin, Lublin, Poland; 2Department of General, Oncological and Minimally Invasive Surgery, 1st Military Clinical Hospital with the Outpatient Clinic in Lublin, Lublin, Poland; 3Department of Clinical Pathomorphology, Faculty of Medicine, Medical University of Lublin, Lublin, Poland; 4Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, PolandCorrespondence: Łukasz PietrzykDepartment of Didactics and Medical Simulation, Faculty of Medicine, Medical University of Lublin, Chodźki 4, Lublin, 20-093, PolandTel +48 814485020Email [email protected]: Despite the continuous improvements in prevention and detection of colorectal cancer (CRC), there is an urgent need to find a sensitive, specific, and noninvasive biomarker to improve the early diagnosis and prognosis of CRC. We aimed to evaluate the tissue TEM8 expression and the serum TEM8 concentration in CRC patients.Methods: The study enrolled 42 CRC patients and 35 controls. Immunohistochemical staining was performed to assess the TEM8 tissue expression, whereas the serum TEM8 concentration was evaluated with the ELISA assay.Results: The expression of TEM8 observed in all primary colorectal tumor samples was significantly correlated with the TNM stages and the presence of lymphovascular invasion. The serum TEM8 concentration was significantly higher in CRC patients than in the controls. The TEM8 level was strongly associated with the TNM stage, depth of invasion, and lymph node and distant metastasis. Patients with a high serum TEM8 concentration had a worse overall survival (OS) rate than CRC patients with a low serum TEM8 level.Conclusion: TEM8 may serve as a biomarker for the diagnosis of CRC and it has value in predicting the prognosis of patients with CRC.Keywords: colorectal cancer, tumor endothelial marker 8, biomarker, ANTXR1, angiogenesis
