Stretchable wireless optoelectronic synergistic patches for effective wound healing

Qian Wang; Siyuan Cai; Guang Yao; Liyuan Zhang; Wenhao Lou; Youxin Chen; Qingqing Li; Maowen Xie; Xingyi Gan; Chenzheng Zhou; Taisong Pan; Min Gao; Kangning Zhao; Zhen Cai; Yuan Lin

doi:10.1038/s41528-024-00351-x

npj Flexible Electronics (Oct 2024)

Stretchable wireless optoelectronic synergistic patches for effective wound healing

Qian Wang,
Siyuan Cai,
Guang Yao,
Liyuan Zhang,
Wenhao Lou,
Youxin Chen,
Qingqing Li,
Maowen Xie,
Xingyi Gan,
Chenzheng Zhou,
Taisong Pan,
Min Gao,
Kangning Zhao,
Zhen Cai,
Yuan Lin

Affiliations

Qian Wang: School of Materials and Energy, University of Electronic Science and Technology of China
Siyuan Cai: Department of Plastic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Guang Yao: School of Materials and Energy, University of Electronic Science and Technology of China
Liyuan Zhang: Department of Plastic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Wenhao Lou: School of Materials and Energy, University of Electronic Science and Technology of China
Youxin Chen: Department of Plastic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Qingqing Li: Department of Plastic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Maowen Xie: School of Materials and Energy, University of Electronic Science and Technology of China
Xingyi Gan: School of Materials and Energy, University of Electronic Science and Technology of China
Chenzheng Zhou: School of Materials and Energy, University of Electronic Science and Technology of China
Taisong Pan: School of Materials and Energy, University of Electronic Science and Technology of China
Min Gao: School of Materials and Energy, University of Electronic Science and Technology of China
Kangning Zhao: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, International School of Materials Science and Engineering, Wuhan University of Technology
Zhen Cai: Department of Plastic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Yuan Lin: School of Materials and Energy, University of Electronic Science and Technology of China

DOI: https://doi.org/10.1038/s41528-024-00351-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Abstract Physiotherapies play a crucial role in noninvasive tissue engineering for wound healing. However, challenges such as the implementation of complex interventions and unsatisfactory treatment outcomes impede widespread application. Here, we proposed a stretchable and wirelessly-powered optoelectronic synergistic patch with a dual-layer serpentine wireless receiver circuit to drive the optoelectronic modulation component. Optimized structure and impedance matching enable the patch to seamlessly attach to irregular skin surfaces and operate robustly over a 30% tensile strain range. Based on Sprague-Dawley rat wound model. The wound closure rate of the optoelectronic synergistic group significantly outperformed both monointervention and blank control groups. Mechanistically, optoelectronic synergistic intervention enhances the secretion of vascular endothelial marker proteins and growth factors, and stabilizes mitochondrial function during oxidative stress. Overall, the scalable amalgamation of flexible electronics, wireless transmission, and synergistic interventions promise to improve wound care.

Published in npj Flexible Electronics

ISSN: 2397-4621 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Electronics; Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.nature.com/npjflexelectron/

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