Nature Communications (Jan 2022)

Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells

  • Quan Wu,
  • Yuichi Shichino,
  • Takaya Abe,
  • Taeko Suetsugu,
  • Ayaka Omori,
  • Hiroshi Kiyonari,
  • Shintaro Iwasaki,
  • Fumio Matsuzaki

DOI
https://doi.org/10.1038/s41467-022-28097-y
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

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The temporal development of tissues and organs may be defined by the genome-wide epigenetic and transcriptional state functioning as the clock. Here the authors found that Fbl, a ribosomal RNA methyltransferase, potentially behaves as a clock during neural stem cell (NSC) development by controlling translational efficiencies of epigenetic modifiers in the cerebral cortex primordium.