Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates

Raghav R. Poudyal; Rebecca M. Guth-Metzler; Andrew J. Veenis; Erica A. Frankel; Christine D. Keating; Philip C. Bevilacqua

doi:10.1038/s41467-019-08353-4

Nature Communications (Jan 2019)

Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates

Raghav R. Poudyal,
Rebecca M. Guth-Metzler,
Andrew J. Veenis,
Erica A. Frankel,
Christine D. Keating,
Philip C. Bevilacqua

Affiliations

Raghav R. Poudyal: Department of Chemistry, The Pennsylvania State University
Rebecca M. Guth-Metzler: Department of Biochemistry, Microbiology, and Molecular Biology, The Pennsylvania State University
Andrew J. Veenis: Department of Chemistry, The Pennsylvania State University
Erica A. Frankel: Department of Chemistry, The Pennsylvania State University
Christine D. Keating: Department of Chemistry, The Pennsylvania State University
Philip C. Bevilacqua: Department of Chemistry, The Pennsylvania State University

DOI: https://doi.org/10.1038/s41467-019-08353-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Membraneless compartments have been theorized to be prebiotic micro-compartments as they spontaneously encapsulate RNA and proteins. Here, the authors report membraneless compartments can enhance RNA chemistries, affecting template directed RNA polymerization and stimulating nucleic acid enzymes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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