Recent advances in managing and understanding diabetic nephropathy [version 1; referees: 3 approved]

Abstract

Diabetic nephropathy is the commonest cause of end-stage renal disease in most developed economies. Current standard of care for diabetic nephropathy embraces stringent blood pressure control via blockade of the renin-angiotensin-aldosterone system and glycemia control. Recent understanding of the pathophysiology of diabetic nephropathy has led to the development of novel therapeutic options. This review article focuses on available data from landmark studies on the main therapeutic approaches and highlights some novel management strategies.

Keywords

• Diabetes & Obesity
• Endocrine & Metabolic Pharmacology
• Hemodynamics, Vasc. Biology & Hypertension Sec. to Kidney Dis.
• Pathophysiology of Chronic Kidney Disease (CKD)
• Renal Pharmacology