PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

Cristiano Sacchetti; Yunpeng Bai; Stephanie M. Stanford; Paola Di Benedetto; Paola Cipriani; Eugenio Santelli; Sonsoles Piera-Velazquez; Vladimir Chernitskiy; William B. Kiosses; Arnold Ceponis; Klaus H. Kaestner; Francesco Boin; Sergio A. Jimenez; Roberto Giacomelli; Zhong-Yin Zhang; Nunzio Bottini

doi:10.1038/s41467-017-01168-1

Nature Communications (Oct 2017)

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

Cristiano Sacchetti,
Yunpeng Bai,
Stephanie M. Stanford,
Paola Di Benedetto,
Paola Cipriani,
Eugenio Santelli,
Sonsoles Piera-Velazquez,
Vladimir Chernitskiy,
William B. Kiosses,
Arnold Ceponis,
Klaus H. Kaestner,
Francesco Boin,
Sergio A. Jimenez,
Roberto Giacomelli,
Zhong-Yin Zhang,
Nunzio Bottini

Affiliations

Cristiano Sacchetti: Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
Yunpeng Bai: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University
Stephanie M. Stanford: Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
Paola Di Benedetto: Rheumatology Division, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila
Paola Cipriani: Rheumatology Division, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila
Eugenio Santelli: Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
Sonsoles Piera-Velazquez: Scleroderma Center and Jefferson Institute of Molecular Medicine
Vladimir Chernitskiy: Division of Rheumatology, Department of Medicine, University of California San Francisco
William B. Kiosses: Core Microscopy Facility, The Scripps Research Institute
Arnold Ceponis: Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
Klaus H. Kaestner: Department of Genetics, Perelman School of Medicine, University of Pennsylvania
Francesco Boin: Division of Rheumatology, Department of Medicine, University of California San Francisco
Sergio A. Jimenez: Scleroderma Center and Jefferson Institute of Molecular Medicine
Roberto Giacomelli: Rheumatology Division, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila
Zhong-Yin Zhang: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University
Nunzio Bottini: Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego

DOI: https://doi.org/10.1038/s41467-017-01168-1
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

Although protein tyrosine kinases are being explored as antifibrotic agents for the treatment of systemic sclerosis, little is known about the function of counteractive protein tyrosine phosphatases in this context. Here, the authors show that PTP4A1 is highly expressed by fibroblasts from patients with systemic sclerosis and promotes TGFβ activity via SRC–ERK–SMAD3 signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal