Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.

Abstract

Three new 9,11-secosterols, pinnisterols A–C (1–3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs).

Keywords

• secosterol
• gorgonian
• Pinnigorgia
• anti-inflammatory
• superoxide anion
• elastase
• cytotoxicity
• HSCs