Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.
Yu-Chia Chang,
Liang-Mou Kuo,
Tsong-Long Hwang,
Jessica Yeh,
Zhi-Hong Wen,
Lee-Shing Fang,
Yang-Chang Wu,
Chan-Shing Lin,
Jyh-Horng Sheu,
Ping-Jyun Sung
Affiliations
Yu-Chia Chang
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
Liang-Mou Kuo
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Tsong-Long Hwang
Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
Jessica Yeh
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Zhi-Hong Wen
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
Lee-Shing Fang
Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
Yang-Chang Wu
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Chan-Shing Lin
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
Jyh-Horng Sheu
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
Ping-Jyun Sung
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
Three new 9,11-secosterols, pinnisterols A–C (1–3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs).
