Nature Communications (Jun 2019)
Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma
- Dieter Henrik Heiland,
- Vidhya M. Ravi,
- Simon P. Behringer,
- Jan Hendrik Frenking,
- Julian Wurm,
- Kevin Joseph,
- Nicklas W. C. Garrelfs,
- Jakob Strähle,
- Sabrina Heynckes,
- Jürgen Grauvogel,
- Pamela Franco,
- Irina Mader,
- Matthias Schneider,
- Anna-Laura Potthoff,
- Daniel Delev,
- Ulrich G. Hofmann,
- Christian Fung,
- Jürgen Beck,
- Roman Sankowski,
- Marco Prinz,
- Oliver Schnell
Affiliations
- Dieter Henrik Heiland
- Translational NeuroOncology Research Group, Medical Center, University of Freiburg
- Vidhya M. Ravi
- Department of Neurosurgery, Medical Center, University of Freiburg
- Simon P. Behringer
- Translational NeuroOncology Research Group, Medical Center, University of Freiburg
- Jan Hendrik Frenking
- Translational NeuroOncology Research Group, Medical Center, University of Freiburg
- Julian Wurm
- Translational NeuroOncology Research Group, Medical Center, University of Freiburg
- Kevin Joseph
- Department of Neurosurgery, Medical Center, University of Freiburg
- Nicklas W. C. Garrelfs
- Translational NeuroOncology Research Group, Medical Center, University of Freiburg
- Jakob Strähle
- Department of Neurosurgery, Medical Center, University of Freiburg
- Sabrina Heynckes
- Translational NeuroOncology Research Group, Medical Center, University of Freiburg
- Jürgen Grauvogel
- Department of Neurosurgery, Medical Center, University of Freiburg
- Pamela Franco
- Translational NeuroOncology Research Group, Medical Center, University of Freiburg
- Irina Mader
- Department of Neuroradiology, Medical Center, University of Freiburg
- Matthias Schneider
- Department of Neurosurgery, University of Bonn
- Anna-Laura Potthoff
- Department of Neurosurgery, University of Bonn
- Daniel Delev
- Department of Neurosurgery, University of Aachen
- Ulrich G. Hofmann
- Department of Neurosurgery, Medical Center, University of Freiburg
- Christian Fung
- Department of Neurosurgery, Medical Center, University of Freiburg
- Jürgen Beck
- Department of Neurosurgery, Medical Center, University of Freiburg
- Roman Sankowski
- Faculty of Medicine, Freiburg University
- Marco Prinz
- Faculty of Medicine, Freiburg University
- Oliver Schnell
- Translational NeuroOncology Research Group, Medical Center, University of Freiburg
- DOI
- https://doi.org/10.1038/s41467-019-10493-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Astrocytes play important roles in neuroinflammatory diseases. Here the authors characterize human glioblastoma-associated astrocytes by gene expression and demonstrate their immunosuppressive role promoted by interactions with tumor and microglia cells in an organotypic model.
