Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis

Jong-Ho Lee; Rui Liu; Jing Li; Chuanbao Zhang; Yugang Wang; Qingsong Cai; Xu Qian; Yan Xia; Yanhua Zheng; Yuji Piao; Qianming Chen; John F. de Groot; Tao Jiang; Zhimin Lu

doi:10.1038/s41467-017-00906-9

Nature Communications (Oct 2017)

Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis

Jong-Ho Lee,
Rui Liu,
Jing Li,
Chuanbao Zhang,
Yugang Wang,
Qingsong Cai,
Xu Qian,
Yan Xia,
Yanhua Zheng,
Yuji Piao,
Qianming Chen,
John F. de Groot,
Tao Jiang,
Zhimin Lu

Affiliations

Jong-Ho Lee: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center
Rui Liu: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center
Jing Li: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center
Chuanbao Zhang: Beijing Neurosurgical Institute, Capital Medical University
Yugang Wang: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center
Qingsong Cai: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center
Xu Qian: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center
Yan Xia: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center
Yanhua Zheng: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center
Yuji Piao: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center
Qianming Chen: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University
John F. de Groot: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center
Tao Jiang: Beijing Neurosurgical Institute, Capital Medical University
Zhimin Lu: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-017-00906-9
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Phosphofructokinase 1 (PFK1) plays a critical role in glycolysis. Here the authors show that PFK1 platelet isoform is upregulated in Glioblastoma and is required for tumor growth mechanistically, such upregulation is due to an increased stability induced by AKT activation via phosphorylation on residue S386.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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