The Role of Methods for Applying Cucurbit[6]uril to Hydroxyapatite for the Morphological Tuning of Its Surface in the Process of Obtaining Composite Materials
Tolkynay Burkhanbayeva,
Arthur Ukhov,
Dina Assylbekova,
Zukhra Mussina,
Irina Kurzina,
Sandugash Abilkasova,
Abdigali Bakibaev,
Manar Issabayeva,
Rakhmetulla Yerkassov,
Zhanat Shaikhova
Affiliations
Tolkynay Burkhanbayeva
Chemistry Department, Faculty of Natural Sciences, L. N. Gumilyov Eurasian National University, Astana 010000, Kazakhstan
Arthur Ukhov
Chemistry Department, National Research Tomsk State University, Arkady Ivanov St. 49, 634028 Tomsk, Russia
Dina Assylbekova
High School of Chemical Engineering and Biotechnology, M. Auezov South Kazakhstan University, Shymkent 160012, Kazakhstan
Zukhra Mussina
Department of Chemistry, Chemical Technology and Ecology, Almaty Technological University, Almaty 050012, Kazakhstan
Irina Kurzina
Chemistry Department, National Research Tomsk State University, Arkady Ivanov St. 49, 634028 Tomsk, Russia
Sandugash Abilkasova
Department of Chemistry, Chemical Technology and Ecology, Almaty Technological University, Almaty 050012, Kazakhstan
Abdigali Bakibaev
Chemistry Department, National Research Tomsk State University, Arkady Ivanov St. 49, 634028 Tomsk, Russia
Manar Issabayeva
Department of Chemistry and Chemical Technology, “Toraighyrov University” NCJSC, Pavlodar 140008, Kazakhstan
Rakhmetulla Yerkassov
Chemistry Department, Faculty of Natural Sciences, L. N. Gumilyov Eurasian National University, Astana 010000, Kazakhstan
Zhanat Shaikhova
Department of Chemistry, Chemical Technology and Ecology, Almaty Technological University, Almaty 050012, Kazakhstan
In this work, composite materials were obtained for the first time using various methods and the dependences of the resulting surface morphologies were investigated. This involves modifying the surface with cucurbit[n]urils, which are highly promising macrocyclic compounds. The process includes applying cucurbit[6]uril to the hydroxyapatite surface in water using different modification techniques. The first method involved precipitating a dispersion of CB[6] in undissolved form in water. The second method involved using fully dissolved CB[6] in deionized water, after which the composite materials were dried to constant weight. The third method involved several steps: first, CB[6] was dissolved in deionized water, then, upon heating, a dispersion of CB[6] was formed on the surface of HA. The fourth method involved using ultrasonic treatment. All four methods yielded materials with different surface morphologies, which were studied and characterized using techniques such as infrared (IR) spectroscopy and scanning electron microscopy (SEM). Based on these results, it is possible to vary the properties and surface morphology of the obtained materials. Depending on the method of applying CB[6] to the surface and inside the HA scaffold, it is possible to adjust the composition and structure of the target composite materials. The methods for applying CB[6] to the hydroxyapatite surface enhance its versatility and compatibility with the body’s environment, which is crucial for developing new functional composite materials. This includes leveraging supramolecular systems based on the CB[n] family. The obtained results can be used to model the processes of obtaining biocomposite materials, as well as to predict the properties of future materials with biological activity.
