Nature Communications (Jan 2019)
Noninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions
Abstract
Most approaches to control gene expression in vivo require generation of knock-in mouse lines and often lack spatiotemporal control. Here the authors develop a photo-activatable Flp recombinase system and demonstrate its use by controlling object-exploration behavior in mice through Cav3.1 silencing.