S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma

Xingtong Wang; Wei Guo; Xiaoju Shi; Yujia Chen; Youxi Yu; Beibei Du; Min Tan; Li Tong; Anna Wang; Xianying Yin; Jing Guo; Robert C. Martin; Ou Bai; Yan Li

doi:10.1186/s13046-022-02589-7

Journal of Experimental & Clinical Cancer Research (Jan 2023)

S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma

Xingtong Wang,
Wei Guo,
Xiaoju Shi,
Yujia Chen,
Youxi Yu,
Beibei Du,
Min Tan,
Li Tong,
Anna Wang,
Xianying Yin,
Jing Guo,
Robert C. Martin,
Ou Bai,
Yan Li

Affiliations

Xingtong Wang: Department of Surgery, School of Medicine, University of Louisville
Wei Guo: Department of Surgery, School of Medicine, University of Louisville
Xiaoju Shi: Department of Surgery, School of Medicine, University of Louisville
Yujia Chen: Department of Surgery, School of Medicine, University of Louisville
Youxi Yu: Department of Surgery, School of Medicine, University of Louisville
Beibei Du: Department of Cardiology, China-Japan Union hospital of Jilin University
Min Tan: Department of Surgery, School of Medicine, University of Louisville
Li Tong: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University
Anna Wang: Department of Hematology, Cancer Center, The First Hospital of Jilin University
Xianying Yin: Department of Hematology, Cancer Center, The First Hospital of Jilin University
Jing Guo: Department of Hematology, Cancer Center, The First Hospital of Jilin University
Robert C. Martin: Department of Surgery, School of Medicine, University of Louisville
Ou Bai: Department of Hematology, Cancer Center, The First Hospital of Jilin University
Yan Li: Department of Surgery, School of Medicine, University of Louisville

DOI: https://doi.org/10.1186/s13046-022-02589-7
Journal volume & issue: Vol. 42, no. 1
pp. 1 – 17

Abstract

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Highlights • Obesity negatively impacted progression-free survival and overall survival in lymphoma patients while an aggressive tumor growth pattern was found in obesity-lymphoma mice. • S1P-S1PR1/S1PR3-YAP signaling mediated lymphomagenesis contributing to tumor aggressive growth in obesity-lymphoma. • S1P-ALOX15 signaling mediated TAMs contributing to immunosuppressive microenvironment in obesity-lymphoma. • S1P-targeted therapy could be potentially effective and immune-enhancive against obesity-lymphomagenesis.

Published in Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://jeccr.biomedcentral.com/

About the journal

Abstract

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