Clinical, Cosmetic and Investigational Dermatology (Apr 2023)
A Case of Multiple Myeloma-Associated Systemic Amyloidosis with Multiple Skin Manifestations as the First Symptom
Abstract
Shunyu Yao,1,2 Suxia Wang,3,* Runxi Yi,1,4,* Liwei Ran,5 Cang Zhang2 1Chinese Traditional Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Department of Dermatology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China; 3Laboratory of Electron Microscopy, Pathological Center, Peking University First Hospital, Beijing, People’s Republic of China; 4Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China; 5Department of Dermatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Liwei Ran, Department of Dermatology, Beijing Chao-Yang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, People’s Republic of China, Tel +86 010 85231374, Email [email protected] Cang Zhang, Department of Dermatology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, 23 Back Street of Art Gallery, Dongcheng District, Beijing, 100010, People’s Republic of China, Tel +86 13693219292, Email [email protected]: An 81-year-old woman presented with purpura, petechiae, ecchymoses, flesh or brown-colored waxy, smooth, papules, warty plaque, nail dystrophy and palmodigital erythematous swelling for more than 6 years. She was diagnosed as multiple myeloma-associated systemic amyloidosis after skin subcutaneous histopathological examinations and relevant examinations such as blood and bone marrow. Systemic amyloidosis is closely related with multiple myeloma (MM). Multiple and pleomorphic skin lesions are not usual among patients with multiple myeloma or systemic amyloidosis.Keywords: multiple myeloma, primary systemic amyloidosis, monoclonal immunoglobulin
