A Rare Presentation of Gall Bladder (GB) Mass in the Form of Mixed Adenoneuroendocrine Carcinoma (MANEC): A Case Report

Abstract

Primary Neuroendocrine Carcinoma (NEC) of gall bladder is extremely rare. The diagnosis is incidental in most cases. Here, we present a case of Mixed Adenoneuroendocrine tumour (MANEC) in a 48-year-old female who presented with pain in abdomen, nausea and loss of appetite and diffuse non-tender lump in right hypochondrium. CECT abdomen showed distended Gall Bladder (GB) with intraluminal polypoidal mass, with multiple liver and retroperitoneal metastasis. Histopathological and immunohistochemistry study revealed MANEC in GB with NEC metastasis in liver. This case highlights the rarity of the disorder and role of immunohistochemical studies and therefore MANEC should be considered as a differential to GB carcinoma.

Keywords

• gall bladder
• immunohistochemistry
• malignant