Nature Communications (Nov 2020)
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
- Antonio Molinaro,
- Pierre Bel Lassen,
- Marcus Henricsson,
- Hao Wu,
- Solia Adriouch,
- Eugeni Belda,
- Rima Chakaroun,
- Trine Nielsen,
- Per-Olof Bergh,
- Christine Rouault,
- Sébastien André,
- Florian Marquet,
- Fabrizio Andreelli,
- Joe-Elie Salem,
- Karen Assmann,
- Jean-Philippe Bastard,
- Sofia Forslund,
- Emmanuelle Le Chatelier,
- Gwen Falony,
- Nicolas Pons,
- Edi Prifti,
- Benoit Quinquis,
- Hugo Roume,
- Sara Vieira-Silva,
- Tue H. Hansen,
- Helle Krogh Pedersen,
- Christian Lewinter,
- Nadja B. Sønderskov,
- The MetaCardis Consortium,
- Lars Køber,
- Henrik Vestergaard,
- Torben Hansen,
- Jean-Daniel Zucker,
- Pilar Galan,
- Marc-Emmanuel Dumas,
- Jeroen Raes,
- Jean-Michel Oppert,
- Ivica Letunic,
- Jens Nielsen,
- Peer Bork,
- S. Dusko Ehrlich,
- Michael Stumvoll,
- Oluf Pedersen,
- Judith Aron-Wisnewsky,
- Karine Clément,
- Fredrik Bäckhed
Affiliations
- Antonio Molinaro
- Wallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg
- Pierre Bel Lassen
- INSERM, Nutrition and Obesities; Systemic Approaches (NutriOmics), Sorbonne Université
- Marcus Henricsson
- Wallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg
- Hao Wu
- Wallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg
- Solia Adriouch
- INSERM, Nutrition and Obesities; Systemic Approaches (NutriOmics), Sorbonne Université
- Eugeni Belda
- INSERM, Nutrition and Obesities; Systemic Approaches (NutriOmics), Sorbonne Université
- Rima Chakaroun
- Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center
- Trine Nielsen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Per-Olof Bergh
- Wallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg
- Christine Rouault
- INSERM, Nutrition and Obesities; Systemic Approaches (NutriOmics), Sorbonne Université
- Sébastien André
- INSERM, Nutrition and Obesities; Systemic Approaches (NutriOmics), Sorbonne Université
- Florian Marquet
- INSERM, Nutrition and Obesities; Systemic Approaches (NutriOmics), Sorbonne Université
- Fabrizio Andreelli
- INSERM, Nutrition and Obesities; Systemic Approaches (NutriOmics), Sorbonne Université
- Joe-Elie Salem
- Assistance Publique Hôpitaux de Paris, Clinical Investigation Center Paris East
- Karen Assmann
- INSERM, Nutrition and Obesities; Systemic Approaches (NutriOmics), Sorbonne Université
- Jean-Philippe Bastard
- Assistance Publique Hôpitaux de Paris, Biochemistry and Hormonology Department, Tenon Hospital
- Sofia Forslund
- Experimental and Clinical Research Center, A Cooperation of Charité-Universitätsmedizin and the Max-Delbrück Center
- Emmanuelle Le Chatelier
- Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay
- Gwen Falony
- Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute
- Nicolas Pons
- Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay
- Edi Prifti
- Integromics Unit, Institute of Cardiometabolism and Nutrition
- Benoit Quinquis
- Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay
- Hugo Roume
- Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay
- Sara Vieira-Silva
- Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute
- Tue H. Hansen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Helle Krogh Pedersen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Christian Lewinter
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Nadja B. Sønderskov
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- The MetaCardis Consortium
- Lars Køber
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Henrik Vestergaard
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Torben Hansen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Jean-Daniel Zucker
- Unité de Modélisation Mathématique et Informatique des Systèmes Complexes, UMMISCO
- Pilar Galan
- Sorbonne Paris Cité Epidemiology and Statistics Research Centre (CRESS), U1153 Inserm, U1125, Inra, Cnam, University of Paris 13, Nutritional Epidemiology Research Team (EREN)
- Marc-Emmanuel Dumas
- Computational and Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London
- Jeroen Raes
- Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay
- Jean-Michel Oppert
- Assistance Publique Hôpitaux de Paris, Pitie-Salpêtrière Hospital, Nutrition department, CRNH Ile de France
- Ivica Letunic
- Biobyte Solutions GmbH
- Jens Nielsen
- Department of Biology and Biological Engineering, Chalmers University of Technology
- Peer Bork
- Structural and Computational Biology, European Molecular Biology Laboratory
- S. Dusko Ehrlich
- Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay
- Michael Stumvoll
- Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center
- Oluf Pedersen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Judith Aron-Wisnewsky
- INSERM, Nutrition and Obesities; Systemic Approaches (NutriOmics), Sorbonne Université
- Karine Clément
- INSERM, Nutrition and Obesities; Systemic Approaches (NutriOmics), Sorbonne Université
- Fredrik Bäckhed
- Wallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg
- DOI
- https://doi.org/10.1038/s41467-020-19589-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
Gut microbial metabolism of nutrients contributes to metabolic diseases, and the histidine metabolite imidazole propionate (ImP) is produced by type 2 diabetes (T2D) associated microbiome. Here the authors report that circulating ImP levels are increased in subjects with prediabetes or T2D in three European populations, and this increase associates with altered gut microbiota rather than dietary histidine.
