Advanced Science (Nov 2021)

Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells

  • Yifan Xie,
  • Feng Xie,
  • Lei Zhang,
  • Xiaoxue Zhou,
  • Jun Huang,
  • Fangwei Wang,
  • Jin Jin,
  • Long Zhang,
  • Linghui Zeng,
  • Fangfang Zhou

DOI
https://doi.org/10.1002/advs.202101672
Journal volume & issue
Vol. 8, no. 22
pp. n/a – n/a

Abstract

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Abstract In the tumor microenvironment, T cells, B cells, and many other cells play important and distinct roles in anti‐tumor immunotherapy. Although the immune checkpoint blockade and adoptive cell transfer can elicit durable clinical responses, only a few patients benefit from these therapies. Increased understanding of tumor‐infiltrating immune cells can provide novel therapies and drugs that induce a highly specific anti‐tumor immune response to certain groups of patients. Herein, the recent research progress on tumor‐infiltrating B cells and T cells, including CD8+ T cells, CD4+ T cells, and exhausted T cells and their role in anti‐tumor immunity, is summarized. Moreover, several anti‐tumor therapy approaches are discussed based on different immune cells and their prospects for future applications in cancer treatment.

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