Nature Communications (Mar 2019)

Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision

  • Philipp Makowka,
  • Tobias Bruegmann,
  • Vanessa Dusend,
  • Daniela Malan,
  • Thomas Beiert,
  • Michael Hesse,
  • Bernd K. Fleischmann,
  • Philipp Sasse

DOI
https://doi.org/10.1038/s41467-019-09322-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 9

Abstract

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Studying adrenergic signalling in the heart requires perfusion with receptor agonists, which lacks cell specificity and spatiotemporal control. Here the authors use the light sensitive G-coupled receptor JellyOp to optogenetically control Gs-signaling in cardiomyocytes and intact hearts with high spatiotemporal precision.