Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision

Philipp Makowka; Tobias Bruegmann; Vanessa Dusend; Daniela Malan; Thomas Beiert; Michael Hesse; Bernd K. Fleischmann; Philipp Sasse

doi:10.1038/s41467-019-09322-7

Nature Communications (Mar 2019)

Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision

Philipp Makowka,
Tobias Bruegmann,
Vanessa Dusend,
Daniela Malan,
Thomas Beiert,
Michael Hesse,
Bernd K. Fleischmann,
Philipp Sasse

Affiliations

Philipp Makowka: Institute of Physiology I, Medical Faculty, University of Bonn
Tobias Bruegmann: Institute of Physiology I, Medical Faculty, University of Bonn
Vanessa Dusend: Institute of Physiology I, Medical Faculty, University of Bonn
Daniela Malan: Institute of Physiology I, Medical Faculty, University of Bonn
Thomas Beiert: Department of Internal Medicine II, University Hospital Bonn, University of Bonn
Michael Hesse: Institute of Physiology I, Medical Faculty, University of Bonn
Bernd K. Fleischmann: Institute of Physiology I, Medical Faculty, University of Bonn
Philipp Sasse: Institute of Physiology I, Medical Faculty, University of Bonn

DOI: https://doi.org/10.1038/s41467-019-09322-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

Read online

Studying adrenergic signalling in the heart requires perfusion with receptor agonists, which lacks cell specificity and spatiotemporal control. Here the authors use the light sensitive G-coupled receptor JellyOp to optogenetically control Gs-signaling in cardiomyocytes and intact hearts with high spatiotemporal precision.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal