Nature Communications (Oct 2019)
Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation
- Alyssa A. Lombardi,
- Andrew A. Gibb,
- Ehtesham Arif,
- Devin W. Kolmetzky,
- Dhanendra Tomar,
- Timothy S. Luongo,
- Pooja Jadiya,
- Emma K. Murray,
- Pawel K. Lorkiewicz,
- György Hajnóczky,
- Elizabeth Murphy,
- Zoltan P. Arany,
- Daniel P. Kelly,
- Kenneth B. Margulies,
- Bradford G. Hill,
- John W. Elrod
Affiliations
- Alyssa A. Lombardi
- Center for Translational Medicine, Lewis Katz School of Medicine at Temple University
- Andrew A. Gibb
- Center for Translational Medicine, Lewis Katz School of Medicine at Temple University
- Ehtesham Arif
- Center for Translational Medicine, Lewis Katz School of Medicine at Temple University
- Devin W. Kolmetzky
- Center for Translational Medicine, Lewis Katz School of Medicine at Temple University
- Dhanendra Tomar
- Center for Translational Medicine, Lewis Katz School of Medicine at Temple University
- Timothy S. Luongo
- Center for Translational Medicine, Lewis Katz School of Medicine at Temple University
- Pooja Jadiya
- Center for Translational Medicine, Lewis Katz School of Medicine at Temple University
- Emma K. Murray
- Center for Translational Medicine, Lewis Katz School of Medicine at Temple University
- Pawel K. Lorkiewicz
- Department of Medicine, Institute of Molecular Cardiology, Diabetes and Obesity Center, University of Louisville
- György Hajnóczky
- Department of Pathology Anatomy and Cell Biology, MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Thomas Jefferson University
- Elizabeth Murphy
- Systems Biology Center, National Heart Lung and Blood Institute
- Zoltan P. Arany
- Translational Research Center, Perelman School of Medicine, University of Pennsylvania
- Daniel P. Kelly
- Translational Research Center, Perelman School of Medicine, University of Pennsylvania
- Kenneth B. Margulies
- Translational Research Center, Perelman School of Medicine, University of Pennsylvania
- Bradford G. Hill
- Department of Medicine, Institute of Molecular Cardiology, Diabetes and Obesity Center, University of Louisville
- John W. Elrod
- Center for Translational Medicine, Lewis Katz School of Medicine at Temple University
- DOI
- https://doi.org/10.1038/s41467-019-12103-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Myofibroblast differentiation contributes to extracellular matrix remodeling and fibrosis. Here, the authors report that alterations in mitochondrial calcium uptake is essential for metabolic reprogramming and epigenetic signaling for activation of the myofibroblast gene program.
