Asian Pacific Journal of Tropical Biomedicine (Jan 2023)

Phellinus igniarius ameliorates renal aging in a rat model of focal and segmental glomerulosclerosis

  • Zhou-Ting Wang,
  • Yue-Wen Tang,
  • Feng Wan,
  • Ru-Chun Yang,
  • Yan Guo,
  • Jie Zheng,
  • You-Gui Li,
  • Wei-Ming He

DOI
https://doi.org/10.4103/2221-1691.383690
Journal volume & issue
Vol. 13, no. 8
pp. 359 – 368

Abstract

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Objective: To comparatively investigate the ameliorative effect of Phellinus igniarius (P. igniarius) on renal aging in a rat model of focal and segmental glomerulosclerosis (FSGS). Methods: The FSGS model was established in rats by uninephrectomy combined with tail vein injection of doxorubicin. The FSGS rats were randomly divided into the model group, the P. igniarius decoction group, the P. igniarius polysaccharides group, and the P. igniarius polyphenols group. Molecular indicators of cell senescence, renal function indexes, and podocyte injury markers were tested after ten weeks of intragastric administration. Besides, the pathological renal lesions and the ultrastructural changes were observed. Results: FSGS developed in the model group within ten weeks and showed segmental glomerular scarring and renal aging. Following the 10-week intervention, 24 h proteinuria, serum creatinine, blood urea nitrogen, P16INK4α, thrombospondin-1, and transforming growth factor-β1 were decreased in each treatment group, whereas albumin, erythropoietin, nephrin, and podocin were increased; the pathological renal injury was alleviated, and the number of senescent cells was reduced, especially in rats treated with P. igniarius decoction. Conclusions: P. igniarius ameliorates renal aging and renal injury in the FSGS rat model. Compared with the effective constituents (polysaccharides and polyphenols), P. igniarius decoction has a better curative effect, which is expected to provide a new therapeutic idea for FSGS.

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