Precision coating of ocular devices/contact lenses by nanoelectrospray additive printing

Abstract

Eye drops are widely used for treating ocular diseases, but with poor bioavailability less than 5%. Drug-eluting contact lenses (DECLs) have been proven to improve the efficacy of treatment. For the manufacturing of DECLs, no method can directly deposit drug formulation on commercial lenses. In this work, a novel additive manufacturing approach, nanoelectrospray (nES), and a custom-built nES printing system was developed to directly deposit drug formulations on the surfaces of commercial contact lenses. As a demonstration, nES was used to coat the model biopolymer, zein, onto commercial lenses. Precise deposition of a ring-shaped polymer layer only on the peripheral region was achieved. For printing optimisation, the spraying width is primarily controlled by the nozzle substrate distance. The coating thickness, which can be used to directly control the drug dose, is subject to the polymer concentration in the formulation, dosing speed and the number of rotations. By using the spray current transient and established scaling law, the predicted spray volume is highly correlated to the experimental results. This study built a firm technological foundation for using nES as a novel additive manufacturing method to produce DECLs with drug coating at the surfaces of contact lenses in pre-defined patterns and locations.

Keywords

• Additive manufacturing
• Nanoelectrospray
• Thin-film coating
• Zein
• Contact lenses
• Patterned deposition