Nature Communications (Oct 2022)
NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart
- Marion Müller,
- Rose Eghbalian,
- Jes-Niels Boeckel,
- Karen S. Frese,
- Jan Haas,
- Elham Kayvanpour,
- Farbod Sedaghat-Hamedani,
- Maximilian K. Lackner,
- Oguz F. Tugrul,
- Thomas Ruppert,
- Rewati Tappu,
- Diana Martins Bordalo,
- Jasmin M. Kneuer,
- Annika Piekarek,
- Sabine Herch,
- Sarah Schudy,
- Andreas Keller,
- Nadja Grammes,
- Cornelius Bischof,
- Anna Klinke,
- Margarida Cardoso-Moreira,
- Henrik Kaessmann,
- Hugo A. Katus,
- Norbert Frey,
- Lars M. Steinmetz,
- Benjamin Meder
Affiliations
- Marion Müller
- Kardiogenetikzentrum Heidelberg, University Hospital of Heidelberg
- Rose Eghbalian
- Kardiogenetikzentrum Heidelberg, University Hospital of Heidelberg
- Jes-Niels Boeckel
- Clinic and Polyclinic for Cardiology, University of Leipzig
- Karen S. Frese
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim
- Jan Haas
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim
- Elham Kayvanpour
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim
- Farbod Sedaghat-Hamedani
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim
- Maximilian K. Lackner
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim
- Oguz F. Tugrul
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim
- Thomas Ruppert
- CFMP, Core Facility for Mass Spectrometry & Proteomics at ZMBH, Heidelberg University
- Rewati Tappu
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim
- Diana Martins Bordalo
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim
- Jasmin M. Kneuer
- Clinic and Polyclinic for Cardiology, University of Leipzig
- Annika Piekarek
- Department of Medicine III, University of Heidelberg
- Sabine Herch
- Department of Medicine III, University of Heidelberg
- Sarah Schudy
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim
- Andreas Keller
- Clinical Bioinformatics, Saarland University
- Nadja Grammes
- Clinical Bioinformatics, Saarland University
- Cornelius Bischof
- Clinic for General and Interventional Cardiology/ Angiology, Herz- und Diabeteszentrum NRW, University Hospital of the Ruhr-Universität Bochum
- Anna Klinke
- Clinic for General and Interventional Cardiology/ Angiology, Herz- und Diabeteszentrum NRW, University Hospital of the Ruhr-Universität Bochum
- Margarida Cardoso-Moreira
- ZMBH, Center for Molecular Biology, Heidelberg University
- Henrik Kaessmann
- ZMBH, Center for Molecular Biology, Heidelberg University
- Hugo A. Katus
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim
- Norbert Frey
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim
- Lars M. Steinmetz
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim
- Benjamin Meder
- Kardiogenetikzentrum Heidelberg, University Hospital of Heidelberg
- DOI
- https://doi.org/10.1038/s41467-022-33658-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Phosphorylation of the essential myosin light chain (ELC) influence actin-myosin crossbridge cycling in the heart. Here, the authors show upregulated ELC-phosphorylation in systolic heart failure and identify NIMArelated kinase 9 to bind to ELC mediating its calcium-dependent phosphorylation.
