Nature Communications (Nov 2020)
The genetic architecture of sporadic and multiple consecutive miscarriage
- Triin Laisk,
- Ana Luiza G. Soares,
- Teresa Ferreira,
- Jodie N. Painter,
- Jenny C. Censin,
- Samantha Laber,
- Jonas Bacelis,
- Chia-Yen Chen,
- Maarja Lepamets,
- Kuang Lin,
- Siyang Liu,
- Iona Y. Millwood,
- Avinash Ramu,
- Jennifer Southcombe,
- Marianne S. Andersen,
- Ling Yang,
- Christian M. Becker,
- Anders D. Børglum,
- Scott D. Gordon,
- Jonas Bybjerg-Grauholm,
- Øyvind Helgeland,
- David M. Hougaard,
- Xin Jin,
- Stefan Johansson,
- Julius Juodakis,
- Christiana Kartsonaki,
- Viktorija Kukushkina,
- Penelope A. Lind,
- Andres Metspalu,
- Grant W. Montgomery,
- Andrew P. Morris,
- Ole Mors,
- Preben B. Mortensen,
- Pål R. Njølstad,
- Merete Nordentoft,
- Dale R. Nyholt,
- Margaret Lippincott,
- Stephanie Seminara,
- Andres Salumets,
- Harold Snieder,
- Krina Zondervan,
- Thomas Werge,
- Zhengming Chen,
- Donald F. Conrad,
- Bo Jacobsson,
- Liming Li,
- Nicholas G. Martin,
- Benjamin M. Neale,
- Rasmus Nielsen,
- Robin G. Walters,
- Ingrid Granne,
- Sarah E. Medland,
- Reedik Mägi,
- Deborah A. Lawlor,
- Cecilia M. Lindgren
Affiliations
- Triin Laisk
- Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu
- Ana Luiza G. Soares
- MRC Integrated Epidemiology Unit at the University of Bristol
- Teresa Ferreira
- Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University
- Jodie N. Painter
- QIMR Berghofer Medical Research Institute
- Jenny C. Censin
- Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University
- Samantha Laber
- Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University
- Jonas Bacelis
- Department of Obstetrics and Gynecology, Sahlgrenska University Hospital Östra
- Chia-Yen Chen
- Analytic and Translational Genetics Unit, Massachusetts General Hospital
- Maarja Lepamets
- Estonian Genome Center, Institute of Genomics, University of Tartu
- Kuang Lin
- Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford
- Siyang Liu
- BGI-Shenzhen, Shenzhen
- Iona Y. Millwood
- Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford
- Avinash Ramu
- Department of Genetics, Washington University in St. Louis
- Jennifer Southcombe
- Nuffield Department of Women’s and Reproductive Health, University of Oxford
- Marianne S. Andersen
- Department of Endocrinology, Odense University Hospital
- Ling Yang
- Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford
- Christian M. Becker
- Nuffield Department of Women’s and Reproductive Health, University of Oxford
- Anders D. Børglum
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Scott D. Gordon
- QIMR Berghofer Medical Research Institute
- Jonas Bybjerg-Grauholm
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Øyvind Helgeland
- Department of Genetics and Bioinformatics, Health Data and Digitalisation, Norwegian Institute of Public Health
- David M. Hougaard
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Xin Jin
- BGI-Shenzhen, Shenzhen
- Stefan Johansson
- KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen
- Julius Juodakis
- Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg
- Christiana Kartsonaki
- Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford
- Viktorija Kukushkina
- Estonian Genome Center, Institute of Genomics, University of Tartu
- Penelope A. Lind
- QIMR Berghofer Medical Research Institute
- Andres Metspalu
- Estonian Genome Center, Institute of Genomics, University of Tartu
- Grant W. Montgomery
- University of Queensland
- Andrew P. Morris
- Estonian Genome Center, Institute of Genomics, University of Tartu
- Ole Mors
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Preben B. Mortensen
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Pål R. Njølstad
- KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen
- Merete Nordentoft
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Dale R. Nyholt
- School of Biomedical Sciences, Faculty of Health, Queensland University of Technology
- Margaret Lippincott
- Reproductive Endocrine Unit, Massachusetts General Hospital
- Stephanie Seminara
- Reproductive Endocrine Unit, Massachusetts General Hospital
- Andres Salumets
- Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu
- Harold Snieder
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Krina Zondervan
- Wellcome Centre for Human Genetics, University of Oxford
- Thomas Werge
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Zhengming Chen
- Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford
- Donald F. Conrad
- Department of Genetics, Washington University in St. Louis
- Bo Jacobsson
- Department of Obstetrics and Gynecology, Sahlgrenska University Hospital Östra
- Liming Li
- Department of Epidemiology & Biostatistics, Peking University Health Science Centre, Peking University
- Nicholas G. Martin
- QIMR Berghofer Medical Research Institute
- Benjamin M. Neale
- Analytic and Translational Genetics Unit, Massachusetts General Hospital
- Rasmus Nielsen
- Department of Integrative Biology, University of California Berkeley
- Robin G. Walters
- Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford
- Ingrid Granne
- Nuffield Department of Women’s and Reproductive Health, University of Oxford
- Sarah E. Medland
- QIMR Berghofer Medical Research Institute
- Reedik Mägi
- Estonian Genome Center, Institute of Genomics, University of Tartu
- Deborah A. Lawlor
- MRC Integrated Epidemiology Unit at the University of Bristol
- Cecilia M. Lindgren
- Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University
- DOI
- https://doi.org/10.1038/s41467-020-19742-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Miscarriage affects around 15% of clinically confirmed pregnancies. Here the authors carry out a large genome-wide association study for sporadic and multiple consecutive miscarriage and suggest links with placental biology.
