Effects of diets containing microwave-irradiated canola meal were evaluated on growth, nutrition performance, carcass composition and digestibility of nutrients in Huso huso fry with 31.18 ± 1.43 g in initial weight during 8-week experiment in a factorial design 4 × 2 with 8 treatments, each with 3 replications. Treatments included T1: %20 canola meal without irradiation; T2, T3 and T4: 20% irradiated-canola meal at 800 watts for 5, 10 and 15 min respectively; T5: 40% canola meal without irradiation; T6, T7, and T8: %40 800 watt – radiated canola meal at 5, 10 and 15 min respectively. At the end of the experiment, according to the results, the effects of diet containing microwave-irradiated canola meal on the final weight, weight gain, specific growth factor, feed conversion ratio and daily growth in H. huso fry were significant (p0.05), but showed significant effect on the carcass ash content (p0.05). So, it can be added to the diet up to 40% without any unfavorable effect on protein digestibility and growth rate.