Synthesis and characterization of critical process related impurities of an asthma drug – Zafirlukast

Gilla Goverdhan; Anumula Raghupathi Reddy; Vurimidi Himabindu; Ghanta Mahesh Reddy

doi:10.1016/j.jscs.2011.06.002

Journal of Saudi Chemical Society (Apr 2014)

Synthesis and characterization of critical process related impurities of an asthma drug – Zafirlukast

Gilla Goverdhan,
Anumula Raghupathi Reddy,
Vurimidi Himabindu,
Ghanta Mahesh Reddy

Affiliations

Gilla Goverdhan: Research and Development, Dr. Reddy’s Laboratories Ltd., Integrated Product Development, Survey Nos. 42, 45, 46, and 54, Bachupally, Qutubullapur, Ranga Reddy District 500 072, Andhra Pradesh, India
Anumula Raghupathi Reddy: Research and Development, Dr. Reddy’s Laboratories Ltd., Integrated Product Development, Survey Nos. 42, 45, 46, and 54, Bachupally, Qutubullapur, Ranga Reddy District 500 072, Andhra Pradesh, India
Vurimidi Himabindu: Institute of Science and Technology, Center for Environmental Science, J.N.T. University, Kukatpally, Hyderabad 500 072, Andhra Pradesh, India
Ghanta Mahesh Reddy: Macleods Pharmaceuticals Ltd., Shanti Nagar, Andheri East, Mumbai 400059, Maharashtra, India

DOI: https://doi.org/10.1016/j.jscs.2011.06.002
Journal volume & issue: Vol. 18, no. 2
pp. 129 – 138

Abstract

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Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the treatment of pulmonary disorders such as asthma. During the process development of zafirlukast, eight process related impurities were observed at a level of 0.1–0.15 area percent. Synthesis and characterization of these impurities and investigation of the root cause of their formation is described.

Published in Journal of Saudi Chemical Society

ISSN: 1319-6103 (Print)
Publisher: Elsevier
Country of publisher: Saudi Arabia
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/journal-of-saudi-chemical-society/

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