Streptococcal Infection: Issues of Pathogenesis, Role in the Formation of Somatic Pathology in Children

Abstract

Streptococcal infections are the most common diseases of bacterial origin. Major importance in human pathology belongs to streptococci serogroup A. There are primary, secondary and rare forms of streptococcal infection. The primary forms include streptococcal lesions of airway, scarlet fever, erysipelas. Secondary forms are diseases of autoimmune nature (acute rheumatic fever, glomerulonephritis, vasculitis, neurological disorders, etc.). The secondary forms of the disease without autoimmune component include peritonsillar abscess, meningitis, bacterial myocarditis, septic complications. Rare or invasive forms of streptococcal infection — enteritis, focal lesions of the internal organs, toxic shock syndrome, primary peritonitis. Pathogenesis of streptococcal infection is represented by several consecutive reactions, including systemic inflammatory response. Promising directions on this issue are: improving the methods for streptococcal infection diagnosis, rational antibiotic therapy, the development of vaccines effective against most types of streptococcus group A.

Keywords

• streptococcus
• infection
• children
• pathogenesis