Evaluation of Visual Acuity of Ametropia with Visual Event-Related Potential Nogo-P3 Component

Abstract

ObjectiveTo analyze the Nogo-P3 component of event-related potential （ERP） in the process of visual acuity processing， to provide electrophysiological evidence for objective evaluation of visual acuity.MethodsTwenty-six subjects with no other ocular diseases except for ametropia were recruited， and all subjects had uncorrected visual acuity both eyes 1/10 （evaluated using Monoyer chart）. Block letter E with different visual angles and directions were used as graphic stimuli. The Go/Nogo paradigm was used for ERP studies. The visual angle of Go stimulation angle was 1°15′， Nogo stimuli were 1°15′， 55′， 24′ and 15′. The visual acuity test was performed on each of the two naked eyes separately in all subjects， and the characteristics of the Nogo-P3 component were analyzed.ResultsThe latency of Nogo-P3 showed no difference between the stimuli of 1°15′ and 55′， and between Nogo stimulation angle 24′ and 15′. There was significant difference between Nogo stimulation angle 1°15′ and 24′， and between Nogo stimulation angle 1°15′ and 15′ （P<0.05）. There was significant difference between Nogo stimulation angle 55′ and 24′， and between Nogo stimulation angle 55′ and 15′ （P<0.05）. No significant differences were observed in the Nogo-P3 amplitude among Nogo stimulation.ConclusionIn the Go/Nogo paradigm, Nogo-P3 can reflect the cognitive response of subjects to Nogo stimulation， which can be used for objective evaluation of visual acuity.

Keywords

• forensic medicine
• event-related potential
• vision
• nogo-p3
• visual acuity
• ametropia
• latency
• amplitude