Nature Communications (Jul 2018)
TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity
- Paloma Riquelme,
- Jan Haarer,
- Anja Kammler,
- Lisa Walter,
- Stefan Tomiuk,
- Norbert Ahrens,
- Anja K. Wege,
- Ivan Goecze,
- Daniel Zecher,
- Bernhard Banas,
- Rainer Spang,
- Fred Fändrich,
- Manfred B. Lutz,
- Birgit Sawitzki,
- Hans J. Schlitt,
- Jordi Ochando,
- Edward K. Geissler,
- James A. Hutchinson
Affiliations
- Paloma Riquelme
- Department of Surgery, University Hospital Regensburg
- Jan Haarer
- Department of Surgery, University Hospital Regensburg
- Anja Kammler
- Department of Surgery, University Hospital Regensburg
- Lisa Walter
- Department of Surgery, University Hospital Regensburg
- Stefan Tomiuk
- Miltenyi Biotec GmbH
- Norbert Ahrens
- Transfusion Medicine, Institute for Clinical Chemistry, University Hospital Regensburg
- Anja K. Wege
- Department of Gynecology and Obstetrics, University Medical Center Regensburg
- Ivan Goecze
- Department of Surgery, University Hospital Regensburg
- Daniel Zecher
- Department of Nephrology, University Hospital Regensburg
- Bernhard Banas
- Department of Nephrology, University Hospital Regensburg
- Rainer Spang
- Department of Statistical Bioinformatics, Institute for Functional Genomics, University of Regensburg
- Fred Fändrich
- Department of Surgery, University Hospital Schleswig-Holstein
- Manfred B. Lutz
- Institute for Virology and Immunobiology, University of Würzburg
- Birgit Sawitzki
- Institute for Medical Immunology, Berlin Charité University Hospital
- Hans J. Schlitt
- Department of Surgery, University Hospital Regensburg
- Jordi Ochando
- Inmunología de Trasplantes, Centro Nacional de Microbiología
- Edward K. Geissler
- Department of Surgery, University Hospital Regensburg
- James A. Hutchinson
- Department of Surgery, University Hospital Regensburg
- DOI
- https://doi.org/10.1038/s41467-018-05167-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 18
Abstract
Regulatory macrophages (Mreg) can directly suppress T effector cell responses. Here the authors show that human Mreg also elicit TIGIT+ regulatory T cells by integrating multiple differentiation signals, and that donor Mreg-induced recipient Tregs may promote kidney transplant acceptance in patients.
