Artificial strain of human prions created in vitro

Chae Kim; Xiangzhu Xiao; Shugui Chen; Tracy Haldiman; Vitautas Smirnovas; Diane Kofskey; Miriam Warren; Krystyna Surewicz; Nicholas R. Maurer; Qingzhong Kong; Witold Surewicz; Jiri G. Safar

doi:10.1038/s41467-018-04584-z

Nature Communications (Jun 2018)

Artificial strain of human prions created in vitro

Chae Kim,
Xiangzhu Xiao,
Shugui Chen,
Tracy Haldiman,
Vitautas Smirnovas,
Diane Kofskey,
Miriam Warren,
Krystyna Surewicz,
Nicholas R. Maurer,
Qingzhong Kong,
Witold Surewicz,
Jiri G. Safar

Affiliations

Chae Kim: Department of Pathology, Case Western Reserve University
Xiangzhu Xiao: Departments of Physiology and Biophysics, Case Western Reserve University
Shugui Chen: Departments of Physiology and Biophysics, Case Western Reserve University
Tracy Haldiman: Department of Pathology, Case Western Reserve University
Vitautas Smirnovas: Departments of Physiology and Biophysics, Case Western Reserve University
Diane Kofskey: Department of Pathology, Case Western Reserve University
Miriam Warren: Department of Pathology, Case Western Reserve University
Krystyna Surewicz: Departments of Physiology and Biophysics, Case Western Reserve University
Nicholas R. Maurer: Department of Pathology, Case Western Reserve University
Qingzhong Kong: Department of Pathology, Case Western Reserve University
Witold Surewicz: Department of Pathology, Case Western Reserve University
Jiri G. Safar: Department of Pathology, Case Western Reserve University

DOI: https://doi.org/10.1038/s41467-018-04584-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Synthetic prions have previously been generated from recombinant rodent PrP. Here the authors generate synthetic human prions, by seeding human PrP with CJD prions, and characterize its infectivity in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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