A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid

Abstract

Amino and trifluoromethyl groups are ubiquitous within medicinal chemistry, but synthesis of fluoroalkylamines normally requires harsh conditions or sensitive reagents. Here the authors report an operationally simple, catalyst-free procedure for the trifluoroethylation of primary and secondary amines.